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Dr. Kerstin Länge

Biosensing and Biofunctionalisation
Phone: +49 721 608-22673
kerstin laengeSyx6∂kit edu

Karlsruhe Institute of Technology
Institute of Microstructure Technology
Hermann-von-Helmholtz-Platz 1
76344 Eggenstein-Leopoldshafen

Short Biography

Kerstin Länge received her Diploma in chemistry in 1997 from the University of Tübingen, Germany. During her PhD thesis she started working on biosensors with label-free detection and flow injection analysis systems. After receiving her PhD from the University of Tübingen in 2000, she joined the Forschungszentrum Karlsruhe, which is now part of the Karlsruhe Institute of Technology (KIT), Germany. She is currently the head of the group “Biofunctionalization” at the Institute of Microstructure Technology of the KIT. Her research activities include surface modifications of biosensors and other bioanalytical devices as well as the development of bioanalytical systems for applications in (bio)medicine and food technology.

Selected Publications

(Review papers are highlighted in bold type)

Gruhl, F.J., Länge, K., Surface acoustic wave (SAW) biosensor for rapid and label-free detection of penicillin G in milk. Food Anal. Methods 7 (2014) 430-437.

Wilhelm, E., Neumann, C., Sachsenheimer, K., Schmitt, T., Länge, K., Rapp, B.E., Rapid bonding of polydimethylsiloxane to stereolithographically manufactured epoxy components using a photogenerated intermediary layer. Lab Chip 13 (2013) 2268-2271.

Gruhl, F.J., Rapp, B.E., Länge, K., Biosensors for diagnostic applications. Adv. Biochem. Eng. Biotechnol. 133 (2013), 115-148.

Länge, K., Gruhl, F.J., Rapp, M., Surface acoustic wave (SAW) biosensors: coupling of sensing layers and measurement. Methods Mol. Biol. 949 (2013), 491-505.

Neuzil, P., Giselbrecht, S., Länge, K., Huang, T.J., Manz A., Revisiting lab-on-a-chip technology for drug discovery. Nat. Rev. Drug Discov. 11 (2012), 620-632.

Gruhl, F.J., Länge, K., Influence of surface preparation parameters on the signal response of an acoustic biosensor for the detection of a breast cancer marker. IEEE Sens. J. 12 (2012), 1647-1648.

Rapp, B.E., Voigt, A., Dirschka, M., Länge, K., Deposition of ultrathin parylene C films in the range of 18 nm to 142 nm: controlling the layer thickness and assessing the closeness of the deposited films. Thin Solid Films 520 (2012), 4884-4888.

Gruhl, F.J., Länge, K., Surface modification of an acoustic biosensor allowing the detection of low concentrations of cancer markers. Anal. Biochem 420 (2012), 188-190.

Waldbaur, A., Rapp, H., Länge, K., Rapp, B.E., Let there be chip – towards rapid prototyping of microfluidic devices: one-step manufacturing processes. Anal. Methods 3 (2011), 2681-2716.

Rapp, B.E., Schickling, B., Prokop, J., Piotter, V., Rapp, M., Länge, K., Design and integration of a generic disposable array-compatible sensor housing into an integrated disposable indirect microfluidic flow injection analysis system. Biomed. Microdevices 13 (2011), 909-922.

Berger, M., Welle, A., Gottwald, E., Rapp, M., Länge, K., Biosensors coated with sulfated polysaccharides for the detection of hepatocyte growth factor / scatter factor in cell culture medium. Biosens. Bioelectron. 26 (2010), 1706-1709.

Rapp, B.E., Gruhl, F.J., Länge, K., Biosensors with label-free detection designed for diagnostic applications. Anal. Bioanal. Chem. 398 (2010), 2403-2412.

Länge, K., Gruhl, F.J., Rapp, M., Influence of preparative carboxylation steps on the analyte response of an acoustic biosensor. IEEE Sens. J. 9 (2009), 2033-2034.

Länge, K., Rapp, M., Influence of intermediate hydrogel layer and amount of binding sites on the signal response of surface acoustic wave biosensors. Sens. Actuators B 142 (2009), 39-43.

Rapp, B.E., Carneiro, L., Länge, K., Rapp, M., An indirect microfluidic flow injection analysis (FIA) system allowing diffusion free pumping of liquids by using tetradecane as intermediary liquid. Lab Chip 9 (2009), 354-356.

Länge, K., Rapp, B.E., Rapp, M., Surface acoustic wave biosensors: a review. Anal. Bioanal. Chem. 391 (2008), 1509-1519.

Länge, K., Rapp, M., Influence of intermediate aminodextran layers on the signal response of surface acoustic wave (SAW) biosensors. Anal. Biochem. 377 (2008), 170-175.

Länge, K., Grimm, S., Rapp, M., Chemical modification of parylene C coatings for SAW biosensors. Sens. Actuators B 125 (2007), 441-446.

Avramov, I.D., Länge, K., Rupp, S., Rapp. B., Rapp, M., Polymer coating behavior of Rayleigh-SAW resonators with gold electrode structure for gas sensor applications. IEEE Trans. Ultrason., Ferroelect. Freq. Contr. 54 (2007),157-166.

Länge, K., Blaess, G., Voigt, A., Götzen, R., Rapp M., Integration of a surface acoustic wave biosensor in a microfluidic polymer chip. Biosens. Bioelectron. 22 (2006), 227-232.

Bender, F., Länge, K., Voigt, A., Rapp, M., Improvement of surface acoustic wave gas and biosensor response characteristics using a capacitive coupling technique. Anal. Chem. 76 (2004), 3837-3840.

Bender, F., Länge, K., Barié, N., Kondoh, J., Rapp, M., On-line monitoring of polymer deposition for tailoring the waveguide characteristics of Love-wave biosensors. Langmuir 20 (2004), 2315-2319.

Länge, K., Herold, M., Scheideler, L., Geis-Gerstorfer, J., Wendel H.P., Gauglitz G., Investigation of initial pellicle formation on modified titanium dioxide (TiO2) surfaces by reflectometric interference spectroscopy (RIfS) in a model system. Dent. Mater. 20 (2004), 814-822.

Länge, K., Bender, F., Voigt, A., Gao, H., Rapp, M., A surface acoustic wave biosensor concept with low flow cell volumes for label-free detection. Anal. Chem. 75 (2003), 5561-5566.

Länge, K., Griffin, G., Vo-Dinh, T., Gauglitz, G., Characterization of antibodies against benzo[a]pyrene with thermodynamic and kinetic constants. Talanta 56 (2002), 1153-1161.

Länge, K., Rapp, F.-R., Gauglitz, G., Brecht, A., Flow injection immunotitration: Extended working range for inhibition type immunodetection. Anal. Chim. Acta 399 (1999), 275-286.