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Chemical surface functionalization of glassy carbon for implantable biosensors

Chemical surface functionalization of glassy carbon for implantable biosensors
Type:Bachelor or Master Thesis or Internship
Supervisor:

Dr. Kerstin Länge

Field of Study:

chemistry, biochemistry, chemical or biochemical engineering

Links:Biosensing and Biofunctionalisation

Job description

Biosensors combine analyte-specific capture molecules, such as antibodies or enzymes, with a transducer, i.e., a device converting signals from one type to another. Thus, biosensors are able to transform a biochemical event on the transducer surface, such as antigen-antibody binding or enzymatic reaction, directly into a measurable output signal. This includes implantable biosensors, which allow continuous monitoring of chemicals in the body with minimal patient intervention. These biosensors are typically based on electrochemical detection. Glassy carbon offers a wide electrochemical stability window, corrosion resistance, good mechanical strength and patternability at the micro-scale. These properties render it very suitable for electrochemical, implantable biosensors. However, the inertness of this material also presents the challenge of efficient activation and functionalization of its surface, which is required for the attachment of biochemical entities, such as enzymes, for sensing purposes. We are currently working on an implantable glassy carbon biosensor that will provide electrical stimulations in addition to detecting the electrochemical signals produced by the biomolecules over extended periods. The development of a suitable chemical surface functionalization method for this biosensor will be the main task assigned to this student research project. It is expected that the student will participate in the experimental design and execution involving various chemical pathways for inducing the desired functionalities on various glassy carbon structures. The project will involve conducting experiments in a chemistry lab. Therefore, a basic understanding of handling chemical reagents is essential. Any prior experience in working in a chemistry lab would be an added advantage. Applications may be submitted in English or German.

 

Starting date: on appointment

Contract duration: 4-6 months

Qualification:
chemistry laboratory experience, willingness to work in a multidisciplinary environment, good command of English language

Technical contact

Dr. Kerstin Länge
Karlsruhe Institute of Technology
Institute of Microstructure Technology
P.O. Box 3640
76021 Karlsruhe

phone: +49 721 608-22673
e-mail: kerstin laengeOme9∂kit edu