Institute of Microstructure Technology (IMT)
Alexander Nesterov-Müller

Prof. Dr. Alexander Nesterov-Müller

  • Karlsruhe Institute of Technology
    Institute of Microstructure Technology
    Hermann-von-Helmholtz-Platz 1
    76344 Eggenstein-Leopoldshafen


Like the Google search engine reacts on your requests, the Molecular Search Engines will experimentally provide you information about relevant molecules or molecule-based processes. Molecular Search Engines copy evolutionary principle: they use the diversity of the combinatorial molecules and the selection of binding events in the array format. Generation of super high density molecular arrays is the main goal of our research. To develop the Molecular Search Engines, we use our ERC-grant awarded approach of combinatorial monomer patterning with “smart” particles. We also develop high throughput screening applications in life and material sciences.



1998    Diploma Physicist with Honor from Lomonosov Moscow State University

2006    Dr. rer.nat. in Physics from University of Heidelberg

2008    Interdisciplinary Habilitation on Molecular High Density Arrays at University of Heidelberg/ German Cancer Research Center

2010    Assistant Professor (Privatdozent) at Karlsruhe Institute of Technology, Institute of Microstructure Technology

2015    Associate Professor (apl. Professor) at Karlsruhe Institute of Technology, Faculty of Mechanical Engineering



Awards: ERC Starting Grant (2011), Helmholtz Association Price (2011), HRJRG-Grant (2011), ERC Proof-of-Principle Grant (2015)


Selected Publications*:


Nesterov-Mueller A & Popov R (2020) On the origin of the standard genetic code as a fusion of prebiotic single-base-pair codes. Preprint, arXiv:2004.09230

Popov R, Shankara G K, von Bojnicic-Kninski C, Barua P, Mattes D, Breitling F, and Nesterov-Mueller A. (2019) Stochastic Deposition of Amino Acids into Microcavities Via Microparticles. Sci Rep 9: 16468.

Popov R, Shankara G K, von Bojnicic-Kninski C & Nesterov-Mueller A (2019) Renaissance Distribution for Statistically Failed Experiments. Int J Mol Sci 20, doi:10.3390/ijms20133250.

Foertsch T C, Davis A T, Popov R, von Bojničić-Kninski C., Held F E, Tsogoeva S B, Loeffler F F, Nesterov-Mueller A (2019) Spatial Modes of Laser-Induced Mass Transfer in Micro-Gaps. Applied Sciences 9 (7), 1303.

Palermo A, Thelen R, Weber L K, Foertsch T, Rentschler S., Hackert V., Syurik J., Nesterov-Mueller A (2019) Vertical Scanning Interferometry for Label-Free Detection of Peptide-Antibody Interactions, High-Throughput 8 (2).

Palermo A & Nesterov-Mueller A (2019) Serological Number for Characterization of Circulating Antibodies. Int J Mol Sci 20, doi:10.3390/ijms20030604.

Nesterov-Mueller A. Auf der Suche nach Kombinatorik: Überlegungen zu den postdigitalen Technologien des 21. Jahrhunderts (German Edition, for students and young scientists), ISBN-10: 1099368944, 2019.

Bojnicic-Kninski C, Bykovskaya V, Maerkle F, Popov R, Palermo A, Mattes D S, Weber L K, Ridder B, Foertsch T C, Loeffler F F, Breitling F, and Nesterov-Mueller A (2016) Selective Functionalization of Microstructured Surfaces by Laser-Assisted Particle Transfer. Adv Funct. Materials, DOI: 10.1002/adfm.201603299.

Loeffler F F, Foertsch T C, Popov R, Mattes D S, Schlageter M, Sedlmayr M, Ridder B, Dang F-X, von Bojničić-Kninski C, Weber LK, Fischer A,Greifenstein J, Bykovskaya V, Buliev I, Bischoff F R, Hahn L, Meier M A R, Bräse S, Powell A K, BalabanT S, Breitling F, Nesterov-Mueller A (2016) High-flexibility combinatorial peptide synthesis with laser-based transfer of monomers in matrix material. Nature Communications, DOI: 10.1038/NCOMMS11844.

Nesterov-Müller A (2016) Erfolgreicher Grenzgang : Bunsen und Kirchhoff: Entdeckung der Spektralanalyse, Physik in unserer Zeit, 47: 233–237, DOI: 10.1002/piuz.201601440.

Maerkle F, Loeffler F F, Schillo S, Foertsch T, Muenster B, Striffler J, Schirwitz C, Bischoff F R, Breitling F, Nesterov-Mueller A (2014) High-Density Peptide Arrays with Combinatorial Laser Fusing, Advanced Materials, V. 26: 3730–3734.

Beyer* M, Nesterov-Mueller* A (shared first authors), Block I, König K, Felgenhauer T, Fernandez S, Leibe K, Torralba G, Hausmann M, Trunk U, Lindenstruth V, Bischoff FR, Stadler V und Breitling F. (2007) Combinatorial synthesis of peptide arrays onto a computer chip’s surface. Science 318, 1888.

Niziev VG and Nesterov AV. (1999) Influence of Beam Polarization on Laser Cutting Efficiency. J. of Phys. D Appl. Phys. 32, 1455-1461.

* My name has changed because of emigration and family reasons. My publications were written under different names: Nesterov AV, Nesterov A, Nesterov-Mueller A