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Magnetic Resonance Microscopy and Related Topics

Prof. Dr. Jan Gerrit Korvink

The Korvink group focuses a large effort on the development of novel concepts for nuclear magnetic resonance microscopy, i.e., obtaining NMR signals from very small volumes of living or inanimate matter. Our approach is to radically miniaturise various components of the NMR signal chain, from resonator to spectrometer, and to develop bespoke methods for novel applications and experiments. For example, we have developed a variety of NMR micro-resonators, parallel acquisition hardware and signal processing, micro-gradient systems, and novel modular probeheads.

Our NMR research work covers a broad set of topics, from novel manufacturing methods and their associated materials, through design methods for component and system performance prediction, to applications in the life sciences, chemistry, and engineering.

Recent NMR research projects include organ-on-a-chip, NMR metabolomics, CMOS ASIC design, and wafer-scale micromanufacturing. We are also active in the area of hyperpolarisation, expecially with Overhauser DNP in microfluidic systems, and in-situ para Hydrogen based hyperpolarisation. New activities have been initiated in NV centres in diamond.

Further research interests cover nano-optics, simulation tool development, and low cost MEMS and NEMS fabrication.

The Korvink group is funded by the ERC, the EU’s Horizon 2020 programme, the Zeiss foundation, the State of Baden-Württemberg, and the DFG.

The following group leaders’ pages present further information on our specific research topics: Vlad Badilita, Mazin Jouda, Neil MacKinnon, and Dario Mager.

 

Teaching, Education, Jobs

We offer lectures at the Department of Mechanical Engineering at the KIT-CS:

  • Introduction to Microsystem Technology I   (winter semester)
  • Introduction to Microsystem Technology II   (summer semester)
  • Introduction to Microsystem Technology - Practical Course   (winter and
summer semester)
  • Seminar on current research in the area of microsystems technology
 
  (winter and
summer semester)
  • Micro Magnetic Resonance   (winter semester)
  • Microsystem product design for young entrepreneurs   (winter semester)
  • NMR micro probe hardware conception and construction   (summer semester)

 

We are offering research topics for bachelor and master thesis to students from all over the world.

Open Ph.D. positons are advertised on KIT’s website for job offers.

NEWS

Two Lenz lenses are arranged in a Helmholtz coil pair. Simulation shows how the Lenz lenses focus magnetic flux. (Figure: Nils Spengler/KIT)
Nuclear Magnetic Resonance: High Sensitivity on Smallest Spaces

For the first time, scientists of IMTEK (Freiburg) and IMT use Lenz lenses for measurements for Nuclear Magnetic Resonance – potential applications in medicine (Figure: Nils Spengler, KIT).
doi:10.1371/journal.pone.0182779

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Picture of the awards ceremony
EUROMAR 2017 Poster Prize goes to Shyamsundar Adhikari

IMT Ph.D. student Shyam S. Adhikari (left) has been awarded with a poster prize for his contribution “On-chip capacitors for MACS NMR detectors” with the EUROMAR 2017 congress on magnetic resonance in Warsaw.
EUROMAR 2017

 
A new MRI scanning method enables precise tracking of the route of nerve fibers. Photo: Niels Schwaderlapp/Department of Radiology, Medical Physics, University Freiburg.
In the test tube instead of under the knife

Freiburg neuroscientists develop new forms of diagnosis and therapy for temporal lobe epilepsy in cooperation with Prof. Korvink of IMT (Photo: N. Schwaderlapp, University Freiburg). Publication in eLife.
doi:10.7554/eLife.25742
Press release University Freiburg

Making of hollow microcoils
Making of hollow microcoils

A process to manufacture solenoidal microcoils relying on a two solvent approach is presented. The corresponding publication has been selected for the J. Micromech. Microeng. 2016 highlights collection.

 
Microscopic components made of silicon (blue) and special polymers (green) convert electrical into optical signals and vice versa. (Graphics: KIT)
Two ERC-POC go to IMT

IMT directors Prof. Koos and Prof. Korvink have been each awarded with “Proof of Concepts Grants” of the ERC for the  SCOOTER and LockChip projects.

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 A branch-stem attachment could serve as a model for technical fiber-reinforced lightweight ramifications (Photo: Hesse/Uni Freiburg).
Deriving Inspiration from the Dragon tree

Researchers demonstrate how a branch-stem attachment could serve as a model for technical fiber-reinforced lightweight ramifications (Photo: Hesse/Uni Freiburg). Publication in Scientific Reports.
doi:10.1038/srep32685

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Tailored Probe Tips for Atomic Force Microscopes
Tailored Probe Tips for Atomic Force Microscopes

Scientists of KIT produce customized probe tips using 3D-Laserlithography (photo: KIT). Publication in Applied Physics Letters.
doi:10.1063/1.4960386

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Miniaturized eyeball: The model of a cyanobacterium shows how light is bundled at one point on its way through the cell. (Figure: Ronald Kampmann/KIT)
Single Cell Organisms With Perspective: How Bacteria “See”

Prof. J. G. Korvink and his team have solved a big mystery: bacteria can see and move towards a light source because they work like tiny eyeballs.
eLife 2016;5:e12620

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