Hyperpolarized magnetic resonance using Parahydrogen

Dr. Sören Lehmkuhl [Contact]

Welcome

… to the homepage of the hyperpolarization research group. We develop hyperpolarization techniques for NMR and MRI to yield new analytical tools and sensors for applications in chemistry, medicine and material science.

 

Research

Our research focuses on Nuclear Magnetic Resonance spectroscopy (NMR) and imaging (MRI). To increase sensitivity, we employ hyperpolarization techniques based on parahydrogen. Within seconds, signals are generated that are many orders of magnitude higher than those afforded in standard NMR and MRI.

Can Parahydrogen Hyperpolarization help in medical diagnosis?

To treat diseases, reliable diagnosis is imperative. This is especially the case for rapidly progressing diseases, where delayed (or even false) diagnosis can lead to incorrect treatment plans or disease progressing beyond treatability. However, in early disease stages, the concentration of indicative biomarkers (e.g. metabolites) is very low, and only rises once the disease has advanced significantly. Many current diagnostic methods are not specific enough or take too much time. We develop spectroscopic methods to detect diseases in body fluids (such as urine) as well as molecular contrast agents aimed towards imaging applications.

The RASER approach allows for unprecedented precision

In our lab, we investigate the RASER phenomenon (RASER = Radiofrequency Amplification by Stimulated Emission of Radiation). Just like its brother the laser, a RASER is based on stimulated emission, but with radio waves instead of light. We develop RASER-based measurement schemes that can improve the resolution in NMR spectroscopy and imaging. On top of that, we study the underlying nonlinear dynamics of the RASER, including regimes that contain chaotic behavior.

News

Lehmkuhl-News
Elene Aslanikashvili recieves HyPERiON fellowship

In her Masters‘ thesis, Elene investigates candidates for water soluble SABRE catalysts, as opposed to the current methanol-based techniques. This would make SABRE much more environmentally friendly and be a huge step towards biocompatibility.

Lehmkuhl
Sören Lehmkuhl becomes Emmy Noether fellow

The DFG has awarded Sören Lehmkuhl with an Emmy Noether Independant Junior Research group. The central research goal will be to develop a new sensor based on the RASER approach.

Wacker
Jakoba Wacker joins the team

Equipped with a M.Sc. degree in Chemistry from the University of Stuttgart Jakoba joins the team as a new PhD student. As an experienced synthetic chemist, she will work on new molecular contrast agents for MRI as well as develop new routes to maximise their polarization.

Lehmkuhl-News
Cover feature article: The Steady-State ALTADENA RASER Generates Continuous NMR Signals

Our newest contribution in ChemPhysChem shows the feasibility of an ALTADENA PHIP RASER as a tool to investigate chaos and nonlinear dynamics using a benchtop setup and sheds light on nonlinear dynamics of the NMR RASER.

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Lehmkuhl-News
Excellent Bachelor thesis by Leon Middendorf

Over the past four months, Leon has designed and built a custom detector and shimset for our EPR magnet enabling many new applications. We are excited about his excellent work and congratulate to a great bachelor thesis: Congratulations Leon!

Lehmkuhl-News
Ahmed Hasaneen recieves HyPERiON fellowship

For his Masters‘ thesis, Ahmed develops a PHIP polarization chamber, which allows for the rapid generation of high polarization. One possible application is enhanced polarization on molecular contrast agents for medical imaging.

Lehmkuhl-News
News Archive
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Publications
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