apl. Prof. Dr. Alexander Nesterov-Müller
- Molecular Search Engines
- Phone: +49 721 608-29253
- alexander nesterov-mueller ∂ kit edu
Research
Like the Google search engine reacts on your requests, the Molecular Search Engines will experimentally provide you information about relevant molecules or molecule-based processes. Molecular Search Engines copy evolutionary principle: they use the diversity of the combinatorial molecules and the selection of binding events in the array format.
Screening for Primordial RNA–Peptide Interactions Using High-Density Peptide Arrays
Highlights:
- High-throughput screening for selective RNA binders;
- Emergence of the standard genetic code from the combinatorial fusion cascade;
- Prediction of ancient "living" membranes.
See for details: https://www.mdpi.com/1422-0067/23/7/3515 ; https://www.mdpi.com/2075-1729/11/9/975
Resemblance-Ranking Peptide Library to Screen for Binders to Antibodies on a Peptidomic Scale
Highlights:
- Human peptidome library design;
- Each antibody has a number of "non-antigenic" selective binders with sub μM affinity;
- Simultaneous measurement of dissociation constants KD of antibodies for 6000 peptides.
See for details: https://www.mdpi.com/1422-0067/23/7/3515
Serological Number for Characterization of Circulating Antibodies
Highlights:
- How to determine the number of linear and conformational monoclonal antibody epitopes in the patient's sera?
- What causes a pre-existing antibody response after vaccination?
See for details: https://www.mdpi.com/1422-0067/20/3/604
Selective Peptide Binders to the Perfluorinated Sulfonic Acid Ionomer Nafion
Highlights:
- Discovery of new functional molecules with a selective affinity for technical polymers
See for details: https://doi.org/10.1002/adfm.202214932
CV
1998 Diploma Physicist with Honor from Lomonosov Moscow State University
2006 Dr. rer.nat. in Physics from University of Heidelberg
2008 Interdisciplinary Habilitation on Molecular High Density Arrays at University of Heidelberg/ German Cancer Research Center
2010 Assistant Professor (Privatdozent) at Karlsruhe Institute of Technology, Institute of Microstructure Technology
since 2015 Associate Professor (apl. Professor) at Karlsruhe Institute of Technology, Faculty of Mechanical Engineering
Awards: ERC Starting Grant (2011), HRJRG-Grant (2011), ERC Proof-of-Principle Grants (2015 and 2017)
Selected Publications:
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Schmidt, D.; Gartner, P.; Berezkin, I.; Rudat, J.; Bilger, M.; Grünert, T.; Zimmerer, N.; Quarz, P.; Scharfer, P.; Brückel, J.; Jung, A. P.; Singh, P.; Pooja, P.; Meier, B.; Stahlberger, M.; Schabel, W.; Bräse, S.; Lanza, G.; Nesterov-Mueller, A. Selective Peptide Binders to the Perfluorinated Sulfonic Acid Ionomer Nafion. Adv Func Mater 2023, https://doi.org/10.1002/adfm.202214932
- Jenne, F.; Berezkin, I.; Tempel, F.; Schmidt, D.; Popov, R.; Nesterov-Mueller, A. Screening for Primordial RNA–Peptide Interactions Using High-Density Peptide Arrays. Life 2023, 13, 796. https://doi.org/10.3390/life13030796
- Jenne, F.; Biniaminov, S.; Biniaminov, N.; Marquardt, P.; von Bojničić-Kninski, C.; Popov, R.; Seckinger, A.; Hose, D.; Nesterov-Mueller, A. Resemblance-Ranking Peptide Library to Screen for Binders to Antibodies on a Peptidomic Scale. Int. J. Mol. Sci. 2022, 23, 3515.
- Babii, O.; Afonin, S.; Diel, C.; Huhn, M.; Dommermuth, J.; Schober, T.; Koniev, S.; Hrebonkin, A.; Nesterov-Mueller, A.; Komarov, I.V.; Ulrich A. Diarylethene-Based Photoswitchable Inhibitors of Serine Proteases. Angew Chem Int Edit 2021, 60, 21789-21794.
- Nesterov-Mueller, A.; Popov, R. The Combinatorial Fusion Cascade to Generate the Standard Genetic Code. Life 2021, 11, 975. https://doi.org/10.3390/life11090975
- Nesterov-Müller, A.; Popov, R. Die Botschaft von LUCA — der letzte universelle gemeinsame Vorfahre. Biospektrum 2020, 26, 488–489 8 (in German).
- Palermo, A.; Nesterov-Mueller, A. Serological Number for Characterization of Circulating Antibodies. Int J Mol Sci 2019, 20, doi:ARTN 604
- Held, F.E.; Guryev, A.A.; Frohlich, T.; Hampel, F.; Kahnt, A.; Hutterer, C.; Steingruber, M.; Bahsi, H.; von Bojnicic-Kninski, C.; Mattes, D.S.; Nesterov-Mueller, A.; Marschall, M.; Tsogoeva, S. Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions. Nat Commun 2017, 8, doi:ARTN 15071
- von Bojnicic-Kninski, C.; Popov, R.; Dorsam, E.; Loeffler, F.F.; Breitling, F.; Nesterov-Mueller, A. Combinatorial Particle Patterning. Adv Funct Mater 2017, 27, doi:ARTN 1703511
- Nesterov-Müller, A.: Erfolgreicher Grenzgang : Bunsen und Kirchhoff: Entdeckung der Spektralanalyse, Physik in unserer Zeit 2016, 47: 233–237, DOI: 10.1002/piuz.201601440 (in German).
- Popova, A.A.; Schillo, S.M.; Demir, K.; Ueda, E.; Nesterov-Mueller, A.; Levkin, P.A. Droplet-Array (DA) Sandwich Chip: A Versatile Platform for High-Throughput Cell Screening Based on Superhydrophobic-Superhydrophilic Micropatterning. Adv Mater 2015, 27, 5217-5222, doi:10.1002/adma.201502115.
- Maerkle, F.; Loeffler, F.F.; Schillo, S.; Foertsch, T.; Muenster, B.; Striffler, J.; Schirwitz, C.; Bischoff, F.R.; Breitling, F.; Nesterov-Mueller, A. High-Density Peptide Arrays with Combinatorial Laser Fusing. Adv Mater 2014, 26, 3730-3734, doi:10.1002/adma.201305759.