We are developing new BioMEMS components, which can be used in different fields of biomedicine, biology and biotechnology. These micro components are fabricated using the micro technologies available at the IMT and the KNMF. Part of this R&D work is done in close collaborations with different scientific and industrial partners.
Typical applications are found in biomedical and bioanalytical microfluidic devices for PoCT (Point-of-Care-Testing). We also optimize existing medical products through the integration of NEMS- and MEMS parts, like surfaces from implants. We are developing and realizing new BioMEMS based devices for Minimally Invasive Surgery; Neurosurgery and Heart Surgery in combination with Interventional Cardiology.
Micro- and nanofluidic systems with integrated (bio) sensors, such as miniaturized analysis systems (µTAS systems, lab-on-chip systems), spectroscopic flow measurement cells or miniaturized bioreactors, are increasingly required for many novel applications and measurements in modern biology, biotechnology, (bio)chemistry, pharmaceutical industry, analytical and clinical chemistry, environmental analysis, process control, food chemistry, and food monitoring.
The understanding and control of the transport and interactions of biogenous substances, such as proteins, are decisive for further developments in the fields of medicine, pharmacy, and other biotechnologies. Our interest focuses in particular on processes on the cellular and molecular level. These processes take place nearly exclusively in liquids. We are developing microfluidic systems, by means of which processes on the intra- and intercellular scale can be studied.
Cell-on-Chip and Organ-on-Chip
In the research of diseases or for drug screening, so-called in-vivo systems are to be increasingly used in the future. Instead of animal experiments chip-based systems can be used realized which suitable cell material. Until now we have realized microfluidic devices for stem-cell research and systems that can adjust part of blood vessels. These devices can be used for tumor research, e.g. for optically tracking the tumor cells during an extravasations process into surrounding tissue. In other applications we have realized systems for simulation the blood brain barrier.
Teaching, Education, Jobs
We offer lectures at the Department of Mechanical Engineering at the KIT-CS:
|• BioMEMS-I||(Prof. Guber; in winter semester)|
|• BioMEMS-II||(Prof. Guber; in summer semester)|
|• BioMEMS-III||(Prof. Guber; in summer semester)|
|• BioMEMS-IV||(Prof. Guber & co-workers; in winter and summer semester)|
|• BioMEMS-Seminar||(Prof. Guber; in winter and summer semester)|
We are offering research topics for bachelor and master thesis to students from all over the world as well as interships.
Typically 4 to 5 Ph.D. students are doing their Ph.D. work in our groups. Open positions will be advertised on KIT’s website for job offers.